Cytokine profiling: variation in immune modulation with preterm birth vs. uncomplicated term birth identifies pivotal signals in pathogenesis of preterm birth

Chemokines Profiling of Patients with Preterm Birth

INTRODUCTION Nowadays it is thought that the main cause of premature birth is subclinical infection. However, none of the currently used methods provide effective prevention to preterm labor. The aim of the study was to determine the concentration of selected chemokines in sera of patients with premature birth without clinical signs of infection (n = 62), threatened preterm labor (n = 47), and ...

Preterm birth

Association of preterm birth with long-term survival, reproduction, and next-generation preterm birth.

CONTEXT Preterm birth is a major cause of infant morbidity and mortality. Less is known about long-term health among persons born preterm. OBJECTIVE To determine the long-term effects of preterm birth on survival, reproduction, and next-generation preterm birth. DESIGN, SETTING, AND PARTICIPANTS Population-based, observational, longitudinal study using registry data from 1,167,506 singleton...

Placenta in Preterm Birth

To the perinatal pathologists, preterm births are those occurring at less than 37 weeks of gestation. In almost all countries with reliable data, preterm birth rates have increased worldwide. The complications of preterm birth due to prematurity are often serious com‐ munity health problems and account for 75% of perinatal mortalities and more than 50% of long-term infant morbidities [1]. Globa...

The immune consequences of preterm birth

Preterm birth occurs in 11% of live births globally and accounts for 35% of all newborn deaths. Preterm newborns have immature immune systems, with reduced innate and adaptive immunity; their immune systems may be further compromised by various factors associated with preterm birth. The immune systems of preterm infants have a smaller pool of monocytes and neutrophils, impaired ability of these...